DOI
10.34229/KCA2522-9664.25.6.16
UDC 51-7.51-76
Y. Sokol
National Technical University "Kharkiv Polytechnic Institute", Kharkiv, Ukraine,
sokol@kpi.kharkov.ua
S. Lapta
Ukrainian State University of Railway Transport, Kharkiv, Ukraine,
stas69@ukr.net
O. Soloviova
Ivan Kozhedub Kharkiv National Air Force University, Kharkiv, Ukraine,
olga01@ukr.net
CYBERNETIC MODELING OF INTESTINAL GLUCOSE ABSORPTION
INTO HUMAN BLOOD UNDER NORMAL CONDITIONS
Abstract. This article presents, for the first time, a solution to the pressing problem of mathematically modeling the process of glucose absorption from the human intestine under physiological (normal) conditions, taking into account intestinal motility. Until recently, modern clinical data and even appropriate methods for obtaining such data have been virtually absent in the fields of physiology and medicine. This problem constitutes the initial stage in more in-depth investigations of intestinal glucose absorption mechanisms, which have gained particular relevance due to the growing need to improve existing digital tools for processing and recording related medical and diagnostic information, as well as to develop new methodological approaches. This article for the first time establishes the actual form of the glucose absorption rate function from the human intestine under physiological (normal) conditions. The derived function is consistent both with the available indirect averaged clinical data and with established concepts in gastroenterology and human physiology. The application of the results obtained in this study will undoubtedly enhance the quality of diabetes mellitus diagnosis — particularly in identifying disorders of glucose homeostasis — and contribute to the improvement of automatic insulin pump control systems.
Keywords: absorption of glucose from the human intestine into the blood in normal, cybernetic mathematical model, numerical experiments, parametric model identification.
full text
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