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Cybernetics And Systems Analysis
International Theoretical Science Journal
Volume 55 >>> № 1 JANUARY — FEBRUARY 2019
UDC 519.217.2
I.V. Sergienko1, B.A. Biletskyy2, A.M. Gupal3, M.A. Gupal4


1 V.M. Glushkov Institute of Cybernetics of National Academy
of Sciences of Ukraine, Kyiv, Ukraine

 ikcab806@gmail.com

2 V.M. Glushkov Institute of Cybernetics of National Academy
of Sciences of Ukraine, Kyiv, Ukraine

 borys.biletskyy@gmail.com

3 V.M. Glushkov Institute of Cybernetics of National Academy
of Sciences of Ukraine, Kyiv, Ukraine

 gupalanatol@gmail.com

4 V.M. Glushkov Institute of Cybernetics of National Academy
of Sciences of Ukraine, Kyiv, Ukraine

 kitgupal@gmail.com

OPTIMAL NOISE-IMMUNE GENETIC CODES

Abstract. Optimal genetic codes are constructed using DNA symmetry, whose noise immunity with respect to polarity of amino acids in case of mutations in nucleotides is much greater than immunity of standard codes. Noise immunity of optimal symmetric and non-symmetric genetic codes is analyzed. Databases of genetic diseases are used to show that optimal symmetric code for which symmetry holds in half of cases keeps polarity of amino acids at mutations in first and second nucleotides of codon as compared with standard code.

Keywords: genetic code, symmetry in DNA, mutations in nucleotides, noise immunity, amino acid, codon.



FULL TEXT

REFERENCES

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  2. Gupal A.M., Sergienko I.V. DNA symmetry. Methods of recognition of discrete sequences. Kiev: Nauk. dumka, 2016. 228 p.

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  4. Mednikov B.M. Axioms of biology. Moscow: Znaniye, 1982. 136 p.

  5. Gupal A.M., Gupal N.A., Ostrovsky A.V. Symmetry and properties of recording genetic information in DNA. Problemy upravleniya i informatiki. 2011. № 3. P. 88–94.

  6. Leninger A. Fundamentals of biochemistry (Russian translation). V. 3. Moscow: Mir, 1985. 320 p.

  7. Brown T.A. Genomes. Moscow; Izhevsk: Institute of Computer Studies, 2011. 922 p.

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